Guy Lyons obtained his PhD from the University of Sydney and then undertook postdoctoral training at the University of Alabama at Birmingham, USA, and Université Louis Pasteur, Strasbourg, France. He returned to Australia to join the Kanematsu Laboratories, discovering the requirement of two types of cells for breast cancer to make enzymes that enable them to break down surrounding tissues.
He undertook a Senior Research Fellowship at NIH in 2004-5, where he began studying head and neck cancer in the laboratories of Dr Silvio Gutkind, discovering that an epithelial-mesenchymal transition caused head and neck cancer cells to create a pro-inflammatory microenvironment.
Joining the Centenary Institute in 2015 and he continued his research on cancer and other diseases of stratified squamous epithelia of the oral cavity, skin and cornea.