Topics: Chronic diseases

About the talk: Traditional medicine has only taken us so far in promoting tissue regeneration. Extracellular vesicles (EVs) – cell-drived membranous nano-structures – have been hailed as the next generation in regenerative medicine. EVs ferry hundreds of bioactive molecules such as proteins, lipids and RNAs to synergistically influence the behaviour of multiple target cells in a ...

About the talk: INPP4B suppresses PI3K/AKT signalling by converting PI(3,4)P 2 to PI(3)P and we recently demonstrated INPP4B facilitates class PI3Kα crosstalk with Wnt signalling in ER+ve breast cancer on late endosomes. We observed in these studies that the conversion ofPI(3,4)P 2 to PI(3)P on late endosomes by INPP4B, was associated an increase in the ...

Abstract: Lipids comprise thousands of individual species, spanning many classes and subclasses and are integral to cellular signalling, metabolism and function. Genome-wide association studies (GWAS) of lipid species can provide novel insights into human physiology, inborn errors of metabolism andmechanisms for complex traits and diseases. We integrated lipidomics and genomics to unravel the genetic architecture ...

This year’s Meeting sponsored by AstraZeneca and GSK, will be held at the Centenary Institute on Thursday 17 and Friday 18 November.

About the talk: In this presentation, Connie will go through some of our recent published and unpublished work on the effect of stroke on the lung neutrophil function and gut barrier integrity. Connie and her team believe revealing the underlying mechanisms behind stroke-induced impairment of these vulnerable mucosal sites will lead to the discovery of ...

Ever wondered what it’s like to be a scientist?

The 17th Annual NAMe meeting is a two day event designed to highlight emerging research in asthma and airways and to engage with new like-minded collaborators.

The 18th Annual NAMe meeting is a two day event designed to highlight emerging research in COPD, Asthma, Fibrosis, Microbiome and Bioinformatics as well as an opportunity to engage with new like-minded collaborators. Connect, Engage, Learn This year’s Meeting, sponsored by AstraZeneca, GSK and Cheisi, will be held at the Centenary Institute on Thursday 10 ...

Jodie Ingles wears many hats. She is a cardiac genetic counsellor, an award-winning scientist, a widely-published researcher, an Associate Professor, as well as a wife and a mum.

Scientists from the Centenary Institute have developed a new therapeutic strategy that could potentially help the fight against advanced-stage melanoma.

Some of our leading cancer researchers, Professor Phil Hansbro, ProfessorÊPeter Hersey, Dr Mainthan Palendira and DrÊJessamy Tiffen have presented their project updates and recent findings to consumers and supporters at our recent consumer engagement session.

Dr Jessamy Tiffen from the Centenary InstituteÕs Melanoma Immunology and Oncology Program has participated in a special ÔWomen in EducationÕ event held at Pymble Ladies College, Sydney.

Cancer Council NSW has awarded funding to 14 ground-breaking cancer research projects including three to the Centenary Institute.

The official launch of the National Drug Discovery Centre (NDDC) has seen Centenary Institute researcher, Associate Professor Anthony Don, announced as one of the first recipients of Australian Government funding that will give him heavily subsidised access to the new CentreÕs advanced drug screening facilities. The opportunity will fast-track Associate Professor DonÕs research into treating type 2 diabetes.

The Centenary InstituteÕs Dr Stefan Oehlers (Immune-vascular Interactions Laboratory within the Tuberculosis Research Program), Dr Jessamy Tiffen (Melanoma Oncology and Immunology Program) and Dr Hui Emma Zhang (Liver Enzymes in Metabolism and Inflammation Program) have all been named on the EducatorÕs list of Higher Education Rising Stars for 2020.

Scientists at the Centenary Institute have reported a new strategy to battle melanoma, the most dangerous form of skin cancer, responsible for approximately 1,700 deaths in Australia each year.

Four scientists from the Centenary Institute have had their world-leading research recognised by being awarded prestigious NSW Cardiovascular Research Capacity Building Grants. The grants will help drive the scientists work focused on improving the health of patients with heart and cardiovascular conditions.

Dr Ulf Schmitz, Head of the Centenary InstituteÕs Computational BioMedicine Laboratory has been recognised as an outstanding investigator in the field of cancer research, being awarded an NHMRC Investigator Grant.

Centenary Institute Deputy Director and Director of the Centenary UTS Centre for Inflammation, Professor Phil Hansbro has been elected as a Fellow of the European Respiratory Society (ERS).

Co-operation between cardiovascular researchers from the University of Zurich with researchers from the ÔLiver Enzymes in Metabolism and Inflammation ProgramÕ at the Centenary Institute have produced a breakthrough in understanding how atherosclerotic plaques (fatty deposits in arteries) form and stabilise.

Researchers from the Centenary Institute have discovered a potential new therapy for cerebral cavernous malformations (CCMs), a devastating disease that often affects young people and can result in stroke and seizures.

Understanding the long-term health impacts of bushfire smoke will be the focus of a new study being undertaken at the Centenary Institute and the University of Technology Sydney (UTS).

Professor Phil Hansbro, Deputy Director at the Centenary Institute and Director of the Centenary UTS Centre for Inflammation has been interviewed by Prime7 News on his new study that will be focused on exploring the health impacts of peopleÕs exposure to bushfire smoke.

New research from the Centenary Institute has provided novel insights into the role of these spacer DNA or introns in the development and function of monocytes and macrophages, essential components of the innate immune system.

Centenary Institute scientists have discovered that genes on the X chromosome may be key to the improved survival rates of females with melanoma-as compared to their male counterparts.

The Future Leader Fellowship at the Centenary Institute has been jointly awarded to two outstanding researchers for 2020ÐDr Jessamy Tiffen (left) from the InstituteÕs Melanoma Oncology and Immunology Program and Dr Shweta Tikoo (right) from the InstituteÕs Immune Imaging Program.Ê

An international study led by the University of Glasgow, including collaborators from the Centenary Institute, has identified a new class of drugs that could pave the way to a new treatment for asthma and chronic obstructive pulmonary disease (COPD).

The findings of an international study led by the Centenary Institute suggests that the possibility of high-risk drinkers developing alcohol-induced cirrhosis is in part related to genetic factors.

Research led by the Centenary Institute has shown that a healthy weight and coffee consumption may help lower the risk of high-risk drinkers developing alcohol-induced cirrhosis (scarring of the liver), which causes approximately 300,000 deaths globally each year.

Research led by the Centenary Institute has discovered that the lack of an enzyme in the liver called sphingosine kinase 2 (SphK2) results in pronounced insulin resistance and glucose intolerance, both symptoms of early stage type 2 diabetes.

Professor Phil Hansbro, Director of the Centenary UTS Centre for Inflammation has featured on the current affairs program 60 Minutes, explaining his critical research on bushfire smoke, its impact on the health of Australians and how his work could potentially lead to new prevention and treatment strategies.

Researchers at the Centenary Institute have found that sensitivity of the immune system to ÔgoodÕ gut bacteria is present in zebrafish, proving that the ability of an animal to benefit from good gut bugs is evolutionarily conserved whether you walk or swim.

A ground-breaking discovery by Centenary Institute scientists has provided new understanding as to the nature of proteins and how they exist and operate in the human body.

Research led by the Centenary Institute, the University of Technology Sydney and the University of Queensland has shown for the first time a link between chronic obstructive pulmonary disease (COPD), an often fatal lung condition, and the gut microbiome.

Improving the clinical care of patients with cirrhosis will be the focus of a new three year PhD project being undertaken at the Centenary Institute, Sydney.

Research from the Centenary Institute has found that a new dual drug approach could offer up a highly effective treatment strategy for melanoma, the most serious form of skin cancer responsible for more than 1,700 deaths each year in Australia.

In a comprehensive analysis of human gene activation data, researchers from the Centenary Institute have discovered that the dipeptidyl peptidase-4 (DPP4) gene family is strongly implicated in the development of human hepatocellular carcinoma (HCC), the most common type of primary liver cancer.

Dr Keshav Raj Paudel, an early career researcher at the Centenary UTS Centre for Inflammation has been awarded the prestigious ÔThoracic Society of Australia and New Zealand (TSANZ) Maurice Blackburn Grant-In-Aid for Occupational Lung DiseaseÕ for 2021.

World-class research into melanoma, the deadliest form of skin cancer, has been boosted with Dr Jessamy Tiffen, Head of the Centenary Institute's Melanoma Epigenetics Laboratory, receiving a $447,000 project grant from Cancer Council NSW.

Research shows that inhibiting necroptosis, a form of cell death, could be a novel therapeutic approach for treating chronic obstructive pulmonary disease (COPD), an inflammatory lung condition, also known as emphysema, that makes it difficult to breathe.

Researchers from the Centenary Institute and the Royal Prince Alfred Hospital (RPAH) are co-investigators on three separate liver cancer focused projects that have recently received funding from the Australian GovernmentÕs Medical Research Future Fund (MRFF) and the Cancer Institute NSW.

The Centenary Institute has held its inaugural ‘Inflammation Symposium’ on 13 and 14 July, highlighting the latest in medical research across the field of inflammation and disease.

The Centenary Institute is pleased to note its involvement in, and support of, the newly announced NSW RNA Production and Research Network involving the stateÕs leading universities and other prominent health and medical research organisations.

Research led by the Centenary Institute has found that a compound extracted from a commonly cultivated orchid could be a potential new treatment option for prostate cancer.

Researchers from the Centenary UTS Centre for Inflammation and collaborators have been awarded a seed grant of $20,000 to advance a new treatment strategy for chronic obstructive pulmonary disease (COPD) patients suffering from influenza.

Aster Pijning, PhD candidate at the ACRF Centenary Cancer Research Centre, has had her science recognised with an image from her paper selected for the recent front cover of the prestigious journal ÔBloodÕ.

Australian researchers have been awarded a $5 million National Health and Medical Research Council (NHMRC) Synergy Grant for a project that will advance knowledge of the gut, microbiomes, metabolites and diet, and their role in both causing and potentially treating inflammatory respiratory diseases, particularly chronic obstructive pulmonary disease (COPD).

An international research group led by the Centenary Institute has developed a world first genetic risk score (GRS) test able to identify patients at high-risk of developing alcohol-related cirrhosis.

Researchers from the Centenary Institute have developed a new approach to fighting melanomas that fail to respond – or are resistant – to standard treatments.

Australians will be better protected against the health impacts of climate change, thanks to the Healthy Environments And Lives (HEAL) national research network, just announced by the Australian Government.

World-leading research into cardiovascular disease has been boosted with three researchers from the Centenary Institute securing Cardiovascular Research Capacity Program grants from the NSW Government.

Research led by the Centenary Institute and University of Technology Sydney has identified a small RNA molecule called microRNA-21 as a therapeutic target and its inhibition as a potential treatment for chronic obstructive pulmonary disease (COPD).

The Centenary Institute has announced it will establish a new precision medicine laboratory, enabling world-leading research into the use of theranostics to treat cancer, thanks to a grant from the Australian Cancer Research Foundation (ACRF).

Two Centenary Institute scientists have been awarded grants totalling $4.3 million from the Cancer Institute NSW to undertake critical cancer related medical research.

Professor Philip Hogg, Head, ACRF Centenary Cancer Research Centre, has featured on Nine News explaining his new theranostics research, recently funded by the Cancer Institute NSW. A form of personalised cancer treatment for the patient, the term ‘theranostics’ refers to a combined therapy and diagnostics approach where tumour markers are employed to deliver a therapeutic isotope ...

World-leading research into pancreatic cancer has been boosted with the Centenary Institute’s Professor John Rasko AO awarded a $100,000 ‘Innovation in Early Detection’ grant from The Australian Pancreatic Cancer Foundation. One of the deadliest forms of cancer, the five-year survival rate for pancreatic cancer is less than 12% in Australia. A reason for the low ...

Professor Phil Hansbro, Director of the Centenary UTS Centre for Inflammation has featured in a Good Weekend article discussing the role of inflammation in health. Inflammation is increasingly being found to play crucial roles in the development of many major diseases, including Alzheimer’s, heart disease, cancer, respiratory diseases, diabetes, tuberculosis and COVID-19. “There’s been a ...

Hi, I’m A/Prof Devanshi Seth and I head Centenary’s Alcoholic Liver Disease Laboratory. 

Associate Professor Mathias Francois established the Centenary Institute’s ‘David Richmond Laboratory for Cardiovascular Development: Gene Regulation and Editing’ back in June 2019. It’s the architecture and complexity of the vascular system in humans that he finds particularly fascinating, especially their mode of assembly during embryonic development.

Hi, I’m Mark and I’m Head of the Liver Enzymes in Metabolism and Inflammation Program at Centenary.

Hi, I’m Dr Hui Emma Zhang and I research liver cancer at Centenary.

Hi, I’m Phil Hansbro and I’m Deputy Director at the Centenary Institute as well as Director of the Centenary UTS Centre for Inflammation.

Hi, I’m Patrick and I Head the Liver Immunology Program at Centenary.

Hi, I’m Elinor and I’m post-doctorate researcher at Centenary.

Focus, accuracy and persistence–these are just some of the many qualities possessed by Julie Feng, a researcher in the Centenary Institute’s Gene and Stem Cell Therapy Program and also a world-leading kendo practitioner.

Hi I’m Dr Ulf Schmitz and I lead the Computational BioMedicine Research Laboratory at Centenary.

A medical researcher at the Centenary UTS Centre for Inflammation, Dr Annalicia Vaughan specialises in the gut-lung axis and its role in lung and respiratory diseases.

Researchers at the Centenary Institute and the University of Technology Sydney have identified a new drug target for the treatment and prevention of chronic obstructive pulmonary disease (COPD), an inflammatory lung disease that causes airway blockage and that makes it difficult to breathe.

Vascular endothelial cells serve as a protective barrier in blood vessel walls.

The lymph node is bean shaped mass and is one of approximately 450 in the body.

Originally from Canada, Dr Dan Hesselson, Head of the Centenary Institute’s Directed Evolution Laboratory, has a true passion for ice hockey, a sport he played regularly as a child and one which he still plays recreationally now.