Tiffen
Working closely with collaborators we will look to identify drugs that can be rapidly screened in the laboratory using our extensive pre-clinical in vitro and in vivo melanoma models. This will allow us to study tumour growth, metastases and resistance to therapy.
Our ultimate goal is to apply the knowledge we have gained through this current work in melanoma and expand into other cancer areas which have poor prognosis, such as cancers of the lung, pancreas and brain.
The Epigenetics of Melanoma Program works to understand how epigenetic regulators such as histone modifications drive melanoma progression, immune evasion and response to therapy.
Projects
- The role of histone and chromatin modifier’s in melanoma progression and treatment resistance.
- Identifying novel epigenetic regulators of targeted therapy and immunotherapy resistance.
- Investigating sex differences in X-linked epigenetic regulators of melanoma.
The Epigenetics of Melanoma Program works to understand how epigenetic regulators such as histone modifications drive melanoma progression, immune evasion and response to therapy.
Projects
- The role of histone and chromatin modifier’s in melanoma progression and treatment resistance.
- Identifying novel epigenetic regulators of targeted therapy and immunotherapy resistance.
- Investigating sex differences in X-linked epigenetic regulators of melanoma.
