Lyons Laboratory
The Lyons Laboratory investigates the processes by which normal cells and benign lesions progress to advanced stages of cancer. By identifying the mechanisms that drive their growth and spread, we aim to identify new ways of preventing and treating cancers.
About the Lyons Laboratory
We are investigating ways in which cancer cells interact with each other to promote growth and metastasis, particularly in cancers that arise in the outermost layer of cells in tissues that protect us from the environment, including the skin, mouth and eyes. Treatment of these squamous cell carcinomas and melanomas often involves surgery and radiotherapy, which do not always work, and can leave survivors disabled and disfigured.
Our goal is to identify the genes and cell-to-cell communication pathways that enable malignant interactions between cancer cells. This will enable ourselves and others to design and identify new drugs that block the malignant interactions and which can then be further tested in experimental models.
Centre for Cancer Innovations
- Head and neck cancer
- Oral cancer
- Skin cancer
- Cornea cancer
- Eye cancer
- Molecular biology
- Microscopy imaging
- Genetic models of diseases
Self-organized centripetal movement of corneal epithelium in the absence of external cues
Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
Assembly and activation of the Hippo signalome by FAT1 tumor suppressor
Tracing the fate of limbal epithelial progenitor cells in the murine cornea
Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes
People
-
Associate Professor Guy Lyons
Faculty, Centenary Institute
-
Dr Natnicha Ketchaikosol
PhD Student
-
Dr Mojdeh Abbasi
Postdoctoral Scientist -
Dr Thuy Luong
PhD student -
Hannah Madanowski
Honours Student -
Keya Panchal
Honours student -
Owen Luong
MD Research student
Student Opportunities
Opportunities exist to investigate the interactions between cell clones in cancer, and new ways of treating corneal diseases using stem cells. The projects use live cell and high resolution imaging, methods for genetically modifying cells and computer simulations.
To learn more about student opportunities in the Lyons Laboratory and for all general enquiries relating to our work, please contact Associate Professor Guy Lyons.
