Gamble Laboratory
Ageing is the progressive loss of tissue and organ function over time.
Our focus is on understanding the ageing process (called senescence) of the cells that make up the blood vessels, particularly in the brain, and the impact of these changes in Alzheimer’s disease, cerebral amyloid angiopathy and other cardiovascular disease.
About the Gamble Laboratory
The ageing of cells induces profound changes in their structure and on their function. This cellular ageing is called senescence.
Our focus is on the senescence of endothelial cells, the cells which line all our blood vessels. We aim to:
- understand the molecular and cellular changes in endothelial cells as they become senescent.
- determine the impact of the senescent endothelial cells in Alzheimer’s disease, cerebral amyloid angiopathy and in atherosclerosis
- develop new drugs which will remove the senescent endothelial cells and will mend the damaged blood vessels.
Centre for Healthy Ageing
- Cardiovascular disease
- Alzheimer’s disease
- Atherosclerosis
- Cellular senescence
- In vitro analysis of senescence
- In vivo models of Alzheimer’s disease, atherosclerosis, cerebral amyloid angiopathy.
- Single cell RNA sequencing
- High resolution imaging
Vascular senescence and leak are features of the early breakdown of the blood-brain barrier in Alzheimer’s disease models
The aging endothelium
Therapeutic regulation of VE-cadherin with a novel oligonucleotide drug for diabetic eye complications using retinopathy mouse models
Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells
Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells
People
-
Professor Jenny Gamble
Wenkart Chair of the Endothelium University of Sydney
-
Dr Ka Ka Ting
Senior Scientist
-
Dr Paul Coleman
Senior Scientist
-
Dr Ngan Ching Cheng
Senior Scientist
-
Ms Hanna Gong
PhD Student
Student Opportunities
PhD and Honours projects into understanding vascular ageing
The investigations are focussed on identifying the biological and molecular changes that occur when endothelial cells undergo senescence (ageing) and the impact on diseases such as dementia, diabetes, heart disease and atherosclerosis.
The technologies utilised encompass, gene arrays of aged cells and tissues, molecular dissection of signalling pathways, biochemical analysis of protein structure and functions, in vitro assays of cellular function, state-of-the art imaging of cellular structures and protein localisation, animal models using genetically mutant mice and disease models and when appropriate zebrafish for vascular analysis.
