Bertolino & Bowen Laboratory
The Bertolino & Bowen Laboratory aims to advance our understanding of immune responses in the healthy and diseased liver to improve liver disease outcome. The lab uses unique transgenic mouse models as well as cutting edge cytometry and imaging approaches to address fundamental questions relevant to transplantation, viral hepatitis, fatty liver disease, malaria and gene therapy.
About the Bertolino & Bowen Laboratory
The group is internationally recognised for having made several key contributions to the field of liver immunology. These discoveries, published in pioneering landmark papers, have transformed the field and greatly advanced our knowledge of liver immune responses during infections and in liver transplantation. Although they did not initially conform with existing paradigms, these discoveries are now part of current models and referenced in many immunology textbooks.
Centre for Infection & Immunity
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Associate Professor Patrick Bertolino
Head, Centre for Infection & Immunity
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- Liver Immunology
- Immunology
- Hepatology
- Monocytes and macrophages
- T cells
- Transgenic mouse models
A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs.
A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment.
Hepatocyte entry leads to degradation of autoreactive CD8 T cells.
T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells.
The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity.
People
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Associate Professor Patrick Bertolino
Head, Centre for Infection & Immunity -
Associate Professor David Bowen
Laboratory co-head
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Lior Yoffe
Undergraduate student
Student Opportunities
Postdoctoral and postgraduate students would be trained and supervised by excellent research and clinical scientists internationally recognised for their contribution and expertise to the field. Studies will be performed in state-of-the-art facilities, in direct collaboration with the University of Sydney, UTS and Royal Prince Alfred Hospital.
To learn more about student opportunities in the Bertolino & Bowen Laboratory and for all general enquiries relating to this work, please contact Associate Professor Bertolino or Associate Professor Bowen.
