Izzo Laboratory
The Izzo Laboratory investigates the immune response induced to pulmonary Mycobacterium tuberculosis infection and to vaccination with new tuberculosis vaccines. Preclinical animal models are used to provide a systematic analysis of immunity using technologies such as flow cytometry, transcriptomics and epigenetics. The overall goal is to determine mechanisms of immunity that will end the tuberculosis pandemic.
About the Izzo Laboratory
Our work focuses on using the preclinical mouse model to understand the immune response to infection with Mycobacterium tuberculosis. We are investigating how co-infection with other infectious pathogens affects the immune response to M. tuberculosis infection. We work with collaborators (Dr. Alyson Ashe, University of Sydney) to investigate cellular mechanisms associated with co-infection. Another line of investigation in our lab is to understand how new tuberculosis vaccines function to induce protective immunity. We work closely with the other investigators in the Tuberculosis Research Group to understand the complex interaction between the pathogen and the host immune response.
Centre for Infection & Immunity
- Mycobacterium tuberculosis
- Immunopathogenesis of pulmonary infection
- Vaccine induced immunity
- Preclinical animal models
- Immune response to infectious diseases
- Vaccine induced immune responses
- Mycobacterium tuberculosis culturing
Mouse Subcutaneous BCG Vaccination and Mycobacterium tuberculosis Infection Alter the Lung and Gut Microbiota
Pulmonary mucosal immunity mediated through CpG provides adequate protection against pulmonary Mycobacterium tuberculosis infection in the mouse model. A role for type I interferon
Characterizing the BCG Induced Macrophage and Neutrophil Mechanisms for Defense Against Mycobacterium tuberculosis
Evaluation of Peripheral Blood Markers as Early Endpoint Criteria in Guinea Pigs (Cavia porcellus) when Testing Tuberculosis Vaccine Candidates
Humanized NOG mice as a model for tuberculosis vaccine-induced immunity: a comparative analysis with the mouse and guinea pig models of tuberculosis
People
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Professor Angelo Izzo
Laboratory Head
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Dr Isaac Sakala
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Dr Claudio Counoupas
Student Opportunities
We have opportunities for students (undergraduate and postgraduate) and postdoctoral fellows interested in learning about the immune response mechanisms to infectious diseases and vaccines.
To learn more about student opportunities in the Izzo Laboratory and for all general enquiries relating to our work, please contact Professor Izzo.
