Hesselson Laboratory
The Hesselson Laboratory focuses on engineering designer proteins to tackle unmet medical needs. We use directed evolution to enhance or create entirely new functions in proteins from natural or synthetic sources.
About the Hesselson Laboratory
In one project, we lead a network of researchers aiming to prevent heart failure in heart attack survivors. The limited capacity for repair of human hearts represents an urgent unmet clinical need and opportunity for innovative treatments to directly address the underlying pathophysiology. This project focuses on Klf1, which reprograms the cardiac transcription factor network to coordinate heart muscle dedifferentiation and proliferation after cardiac injury in some animals. We are applying AI-assisted protein design and mammalian directed evolution to engineer novel cardioregenerative therapeutics and deliver them at the right time and place to unlock the regenerative potential of human hearts.
Centre for Biomedical AI
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Associate Professor Daniel Hesselson
Head, Centre for Biomedical AI
- Cardiovascular disease
- Diabetes
- Cancer
- Synthetic Biology
- Directed Evolution
A chimeric viral platform for directed evolution in mammalian cells
The VEGAS Platform Is Unsuitable for Mammalian Directed Evolution
Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish
Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy
Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs
People
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Associate Professor Dan Hesselson
Head of Centre for Biomedical AI
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Dr Alex Cole
Research Officer -
Dr. Lise Hunault
Research Officer -
Dr. Manuela Florido
Research Officer -
Dr. Nishanthi Mathiyalagan
Research Officer -
Matt Riley
Honours Student -
Joshua Soon
Dalyell Student -
Abdul Lawal
Biomedical engineering intern
Student Opportunities
Students in our lab will engage in cutting-edge research, gaining hands-on experience in molecular biology techniques, data analysis, and experimental design, while collaborating closely with leading experts in protein design and generative AI.
To learn more about student opportunities in the Hesselson lab and for more information about our generous PhD top-ups, please contact Associate Professor Dan Hesselson.
